Bisnucleophiles
WebMay 27, 2024 · An oxidative [3+3] annulation of atropaldehyde acetals with various 1,3-bisnucleophiles was developed using either N-bromosuccinimide or copper(II) bromide as oxidizing reagent and Brønsted or Lewis acids as catalyst.The [3+3] annulations can be considered mechanistically as oxidizing reagent-induced acid-acid-catalyzed domino … WebOct 26, 2024 · Herein, we report the efficient and facile use of 3-carboxamide oxindoles as 1,3-C,N bisnucleophiles in the reactions with α,β-unsaturated trifluoromethyl ketones, …
Bisnucleophiles
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WebPPh 3 ‑Catalyzed [3 + 2] Spiroannulation of 1C,3N‑Bisnucleophiles Derived from Secondary β‑Ketoamides with δ‑Acetoxy Allenoate: A Route to Functionalized Spiro … WebBrucellosis caused by Brucella suis rarely occurs in domestic animals other than pigs. Epidemics of brucellosis in people have been reported among packing-house workers, …
WebAn iron-catalysed carbene transfer reaction of diazo compounds to isocyanides has been developed. The resulting ketenimines are trapped in situ with various bisnucleophiles to access a range of densely functionalized heterocycles (pyrimidinones, dihydropyrazolones, 1H-tetrazoles) in a one-pot proces … WebOct 23, 2012 · Phosphine-catalyzed (3 + 2) and (3 + 3) annulations between 5-acetoxypenta-2,3-dienoate and 1C,3O-bisnucleophiles are presented. The former …
WebAug 5, 2024 · The introduction of a methyl group and its 13 C and 2 H labeled analogs on Csp 2-centers remains a challenging issue in synthetic chemistry.While the photoredox/Ni dual catalysis has proven to constitute a valuable methodology for the forging of Csp 2 −Csp 3 bonds, the high difficulty to generate the methyl radical and to control its reactivity has … WebJun 17, 2024 · β-Ketoesters as Mono- or Bisnucleophiles: A Concise Enantioselective Total Synthesis of (-)-Englerin A and B. A short enantioselective total synthesis of …
WebPPh 3 ‑Catalyzed [3 + 2] Spiroannulation of 1C,3N‑Bisnucleophiles Derived from Secondary β‑Ketoamides with δ‑Acetoxy Allenoate: A Route to Functionalized Spiro N‑Heterocyclic Derivatives Author links open overlay panel Jiaojiao Xing † , Yu Lei † , Yu-Ning Gao † , Min Shi †, ‡, §
To a freshly prepared solution of sodium methoxide containing sodium (0.05 g, 2.4 mmol) dissolved in methanol (6 mL), cysteamine hydrochloride (0.13 g, mmol) was added. After stirring under N2 atmosphere for 30 min at r.t, imidate (1 mmol) was added. The mixture was stirred again until the total disappearance … See more To a stirred solution of imidate (13.5 g, 0.1 mol) and pyridine (8.84 mL, 0.11 mol) dissolved in dry Et2O (100 mL). Ethyl chloroformate … See more To a well-stirred solution of imidate (1 mmol) and a catalytic amount of acetic acid (1.7 μL) in Toluene (2 mL). Ethylenediamine (0.07 g, 1.2 mmoL) was added slowly. The reaction mixture was refluxed for 2 h. After … See more Viscous oil, yield: 89%. 1H-NMR (300 MHz, CDCl3) δ: 1.14 (s, 3H), 1.15 (s, 3H), 2.38 (sept, JH–H = 6 Hz, 1H), 3.39 (q, JH–H = 6 Hz, 2H); 3.70 (t, JH–H = 9 Hz, 2H). 13C NMR … See more biomol nmr assignWeb1).18–22 The action of bisnucleophiles, such as diamines, on compounds 1a , b was mechanistically expected to result in a one-step spiro-to-spiro ring transformation of the chroma- daily temp logWebOver the past few decades, transition metals have found wide applications in the development of selective oxidative transformations mediated by molecular oxygen. Due to the benign nature of molecular oxygen as an oxidant and an increasing awareness of green chemistry practice, tremendous progress has been made towards the development of Cu … biomol green assayWebFeb 19, 2024 · A wide variety of bisnucleophiles can add across the α,β-unsaturated acylazoliums to form various five and six-membered heterocycles and carbocycles. Moreover, suitably substituted nucleophiles can add to this intermediate and result in valuable products following cascade processes. Employing chiral NHCs in the process … daily temperature statWebMay 30, 2024 · A straightforward access to tricyclic indoles bearing 3,4-fused seven-membered rings has been established by using 4-aminoindoles as 1,4-bisnucleophiles … daily temporaryWeb职称：教授、博士生导师. 部门：化学学院. 联系方式：. Tel: 86-512-65880307. Fax: 86-512-65880307. Email:[email protected]. 课题组网站. Research Interests: Applied synthetic organic chemistry: Organic reactions of isocyanides; Multicomponent reactions or tandem reaction synthesis of biologically active heterocyclic ... biomol plymouth meeting paWebMay 30, 2024 · Abstract. A straightforward access to tricyclic indoles bearing 3,4-fused seven-membered ring has been established by using 4-aminoindoles as 1,4-bisnucleophiles in three-component reactions. 1H ... daily temperatures gfg