WebCarboplatin is a cisplatin derivative and shares the same mechanism of action. Highly reactive platinum complexes are formed intracellularly. These complexes inhibit DNA synthesis through covalent binding of DNA molecules to form intrastrand and interstrand DNA crosslinks. Carboplatin is considered to be cell cycle phase-nonspecific, but recent ... WebProduct Name: Carboplatin Injection Manufacturer Name: Fresenius Kabi USA, LLC Address: Three Corporate Drive Lake Zurich, Illinois 60047 General Phone Number: …
Chemotherapy and Other Hazardous Drugs Safe Use …
WebPercentages apply to Carboplatin Injection as a single agent or to both Carboplatin Injection and cyclophosphamide in combination. In the controlled studies, dosages were also adjusted at a lower level (50% to 60%) for severe myelosuppression. Escalations above 125% were not recommended for these studies. >100,000 >2,000: 125%: 50–100,000: ... WebDescriptions Carboplatin belongs to the group of medicines known as alkylating agents. It is used to treat cancer of the ovaries. It may also be used to treat other kinds of cancer, as determined by your doctor. Carboplatin interferes with the growth of cancer cells, which eventually are destroyed. get sticky notes without microsoft store
Carboplatin - SCBT
WebSingle-agent carboplatin (area under the curve [AUC] 5 to 6); Weekly paclitaxel 60 mg/m 2 and carboplatin (AUC 2) weekly; or; Every-21-day paclitaxel (175 mg/m 2) and carboplatin (AUC 5). This …. Chemotherapy nephrotoxicity and dose modification in patients with kidney impairment: Conventional cytotoxic agents. WebCompared to cisplatin, carboplatin is less emetogenic and less nephrotoxic. In dogs, the other most common adverse effects relate to gastrointestinal system toxicity … WebCarboplatin, like cisplatin, produces predominantly interstrand DNA cross-links rather than DNA-protein cross-links. This effect is apparently cell-cycle nonspecific. The … get sticky notes back