WebNov 14, 2014 · To more directly evaluate the autophagy dependence of candidate biomarker secretion, we treated the low-autophagy WM793 cell line with Tat-BECN1, an autophagy-inducing peptide composed of the HIV-1 Tat protein transduction domain and the amino acid sequence derived from the Nef-interacting domain of BECN1, an essential autophagy … WebMay 11, 2024 · Following Tat exposure, autophagy-deficient (Becn1+/−) glial cells had significantly and consistently reduced levels in the pro-inflammatory cytokine IL-6 and the …
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http://bbs.jiatuxueyuan.com/home.php?mod=space&uid=596669 WebNov 14, 2014 · To more directly evaluate the autophagy dependence of candidate biomarker secretion, we treated the low-autophagy WM793 cell line with Tat-BECN1, an autophagy-inducing peptide composed of the HIV-1 Tat protein transduction domain and the amino acid sequence derived from the Nef-interacting domain of BECN1, an essential autophagy … hospitals in alvin tx
Different Roles of Beclin1 in the Interaction Between Glia and …
WebInterestingly, co-exposure to morphine and Tat increased sensitivity to pain in Becn1 +/+ mice, but not in similarly treated Becn1 +/-mice. Brain homogenates from Becn1 +/+ mice exposed to Tat, alone and in combination with morphine, showed increased secretion of pro-inflammatory cytokines and reduced expression of growth factors when compared to … WebNov 5, 2024 · Previously we showed that Beclin1 has a regulatory role in the secretion of inflammatory molecules in glia after exposure to morphine and Tat (an HIV protein). Here we show increased secretion of neuronal growth factors and increased neuronal survival in Beclin1-deficient glia. However, without glia co-culture, neurons deficient in Beclin1 … WebRubicon; Tat-BECN1 peptide Autophagy is an essential cellular catabolic process, which is characterized by a transient double-membrane structure called the phagophore, which sequesters cytoplasmic cargoes. The pha-gophore matures into an … hospitals in altoona iowa